Diabetes and its complications are part of the group of chronic degenerative diseases, which have a significant health problem worldwide. Plants such as Spathodea campanulata, are known in traditional African medicine for their hypoglycemic efficacy in the treatment of diabetes. Objective. To assess the effect of oral administration of Spathodea hypoglycemic campanulata in rats with type 2 diabetes and assess the neuroprotective effect in pyramidal neurons of the CA1 of the hippocampus. Materials and methods. Aqueous (EAQSC), acetonic (EASC) and alcoholic extract (EOHSC) were obtained from Spathodea campanulata leaves. The content of phenols, polyphenols, and flavonoids was quantified. The antioxidant activity was evaluated In vitro. Male Wistar rats (from 100g) were used. The animals were randomized into groups (n = 6): Healthy and diabetic with different extracts. Histological analysis of brains was performed to evaluate the population of CA1 pyramidal neurons of the hippocampus. The results were analyzed by ANOVA analysis of variance and post hoc Tukey test. Results. The EAQSC has a medium concentration of secondary metabolites. In antioxidant capacity, the EAQSC and the EASC have a high and the EOHSC medium anti-radical efficiency.
La diabetes y sus complicaciones son parte del grupo de enfermedades crónico degenerativas, que constituyen un problema de salud a nivel mundial. Plantas como Spathodea campanulata, son conocidas en la medicina tradicional africana por su eficacia hipoglucemiante en el tratamiento de la diabetes. Objetivo. Evaluar el efecto hipoglucemiante de la administración oral de Spathodea campanulata en ratas con diabetes tipo 2 y evaluar el efecto neuroprotector en neuronas piramidales del CA1 del hipocampo. Materiales y métodos. Hojas de Spathodea campanulata, se obtuvo el extracto acuoso (EAQSC), acetónico (EASC) y alcohólico (EOHSC); se cuantifico su contenido de fenoles, polifenoles, flavonoides y se evaluó la actividad antioxidante in vitro. Se emplearon ratas macho de la cepa Wistar a partir de 100 g. Los animales fueron aleatorizados en grupos (n=6): Sanos y diabéticos con los distintos extractos. Se realizó el análisis histológico de cerebros, para evaluar la población de neuronas piramidales (segmento CA1) del hipocampo. Los resultados fueron analizados mediante análisis de varianza ANOVA y prueba de Tukey post hoc. Resultados. El EAQSC tiene concentración media de metabolitos secundarios, en capacidad antioxidante, el EAQSC y el EASC tienen elevada y el EOHSC mediana eficiencia antirradical.
