Factor 2 related to nuclear factor erythroid 2 (Nrf2) has a very important function: regulating the transcription of genes responsible for activating the body's antioxidant and detoxification response. The molecular mechanism ...

SARS-CoV-2 is a virus belonging to the Coronaviridae family, Betacoronavirus genus. During the SARS-CoV-2 replication cycle, the main protease Mpro plays a key role by generating a significant number of non-structural ...

The magnitude of the COVID-19 pandemic, the massive isolation as well as the increasing development not only in computational infrastructure but also in specialized user-friendly software, have encouraged a large number ...

The transcription factor Nrf2 is essential to decrease the concentration of reactive oxygen species (ROS) produced in the inflammatory response caused by tissue damage, due to oxidative stress. The disrupt of interaction ...

The functions of different types of cells that constitute a multicellular organism are regulated by signal transduction pathways, whose final goal is target genes regulation. The Notch signaling pathway is mainly involved ...